Selected Publications 2007/2008

Wang, Z.V., Mu, J., Schraw, T.D., Gautron, L., Elmquist, J.K., Zhang, B.B., Brownlee, M. andP.E. Scherer, 2008PANIC-ATTAC, a mouse model for inducible and reversible Beta cell ablation. Diabetes , in press
Schraw, T.D., Wang, Z.V., Halberg, N., Hawkins, M. and P.E. Scherer, 2008.Plasma adiponectin complexes have distinct biochemical characteristics.Endocrinology, 149(5):2270-82
Kim, J-Y, van de Wall, E., Laplante, M., Azzara, A., Trujillo, M.E., Hofmann, S.M., Schraw, T.D., Durand, J.L., Li, H., Li, G., Jelicks, L.A., Mehler, M.F., Hui, D.Y., Deshaies, Y., Shulman, G.I., Schwartz, G.J. and P. E. Scherer. 2007.Obesity-associated improvements in metabolic profile in mice: Rescue of the diabetic phenotype through expansion of adipose tissue mass.J. Clin. Invest., 117(9):2621-2637
Basu, R., Pajvani,U.B., Rizza, R.A. and P.E. Scherer. 2007.Selective downregulation of the high molecular weight form (HMW) of adiponectin in hyperinsulinemia and in type 2 diabetes: differential regulation from non-diabetic subjectsDiabetes, 56(8):2174-7
Wang, Z.V., Schraw, T.D., Kim, J-Y., Khan, T., Rajala, M.W, Follenzi, A. and P.E. Scherer. 2007. Secretion of the adipocyte-specific secretory protein adiponectin critically depends on thiol-mediated protein retention. Mol Cell Biol., (10):3716-3731
Kusminski, C. M., McTernan, P. G., Schraw, T.D., Kos, K., O'Hare, J. P., Ahima, R., Kumar, S. and P. E. Scherer. 2007. Adiponectin complexes in human cerebrospinal fluid: distinct complex distribution from serum Diabetologia, 50(3):634-642

Recent Reviews

Halberg, N., Wernstedt Asterholm, I., and P.E. Scherer. 2008.The Adipocyte as an Endocrine Cell: Endocrinology and Metabolism Clinics of North America, in press
Wang, Z.V. and P.E. Scherer. 2008.ADIPONECTIN, CARDIOVASCULAR FUNCTION AND HYPERTENSION.Hypertension, 75(3):1066-78
Wernstedt Asterholm, I., Halberg, N., and P.E. Scherer. 2007.Mouse Models of Lipodystrophy - Key reagents for the understanding of the metabolic syndrome.Drug Discovery Today:Disease Models, 4(1):17-24
Desruisseaux, M.S., Nagajyothi, Trujillo, M.E., Tanowitz, H.B. and P.E. Scherer. 2007. Adipocyte, adipose tissue and ifectious diease. Infect Immun., 75(3):1066-78

Recent Collaborative Efforts

Nagajyothi, F., Desruisseaux, M.S.,Thiruvur, N., Weiss, L.M., Braunstein, V.L., Albanese, C., Teixeira, M.M., de Almeida, C.J., Lisanti, M.P., Scherer, P.E. and Tanowitz, H.B., 2008Trypanosomacruzi Infection of Cultured Adipocytes Results in an Inflammatory Phenotype, Obesity, in press
Atzmon, G., Pollin, T.L., Crandall, J., Tanner, K., Schechter, C.B., Scherer, P.E., Rincon, M., Siegel, G., Katz, M.,Lipton, R.B., Shuldiner, A.R. and Barzilai, N. 2008Adiponectin levels and genotype: a potential regulator of life span in humans.
Dallaire, P., Bellmann, K., Laplante, M.,Gelinas, S., Centeno-Baez, C., Penfornis, P., Peyot, M.L., Latour, M.G., Lamontagne, J.,Trujillo, M.E.,Scherer, P.E.,Prentki, M., Deshaies, Y. and A. Marette, 2008 Obese mice lacking iNOS are sensitized to the metabolic actions of PPARyagonism. Diabetes, in press
Sommer, G., Weise, S., Kralisch, S., P.E. Scherer, Lossner, U., Bluher, M., Stumvoll, M. and M. Fasshauer, 2008The adipokine SAA3 is induced by interleukin-1beta in mouse adipocytes. J Cell Biochem , in press
Wildman, R.P., Mancuso, P., Wang, C., Kim, M., P.E. Scherer and M.R. Sowers, 2008.Adipocytokine and ghrelin levels in relation to cardiovascular disease risk factors in women at midlife: longitudinal associations. 2008Int J Obes (Lond), in press
Sinha, M.K., Songer, T., Xiao, Q., Sloan, J.H., Wang, J., Ji, S., Alborn, W.E., Davis, R.A., Swarbrick, M.M., Stanhope, K.L., Wolfe, B.M., Havel, P.J., Schraw, T., Konrad, R.J., Scherer P.E. and J.S. Mistry. 2007.Analytical Validation and Biological Evaluation of a High Molecular-Weight Adiponectin ELISA.Clin Chem., 53(12):2144-51
Muse, E.D., Lam, T.K., Scherer, P.E. and L. Rossetti, 2007.Hypothalamic resistin induces hepatic insulin resistance.J. Clin. Invest., 117: 1670-1678
Kaplan, R.C., Ho, G.Y., Xue, X., Rajpathak, S., Cushman, M., Rohan, T.E., Strickler, H.D., Scherer, P.E. and K. Anastos. 2007.Within-Individual Stability of Obesity-Related Biomarkers among Women.Cancer Epidemiol Biomarkers Prev., 16(6):1291-3.
Lin, H.V., Kim, J.Y., Pocai, A., Rossetti, L., Shapiro, L., Scherer, P.E. and D. Accili. 2007.Adiponectin resistance exacerbates insulin resistance in insulin receptor transgenic knockout mice. Diabetes, 16(6):1291-3
Semple, R.K., Halberg, N.H., Burling, K., Soos, M.A., Shraw, T., Luan, J.,Cochran, E.K., Dunger, D.B., Wareham, N.J., P.E. Scherer, Gorden, P. and S. O'Rahilly, 2007Paradoxical elevation of hign molecular weight adiponectin in acquired extreme insulin resistance due to insulin receptor antibodies. Diabetes, 56(6):1712-17
Cnop, M., Vidal, J., Hull, R.L., Utzschneider, K.M., Carr, D.B., Schraw, T., Scherer, P.E., Boyko, E.J., Fujimoto, W.Y., and S.E. Kahn. 2007Progessive Loss of Beta-Cell Function Leads to Worsening Glucose Tolerance in First-Degree Relatives of Subjects with Type 2 Diabetes.Diabetes Care, 30(3):677-682
Kim, J.J., Kido, Y., Scherer, P.E., White, M.F.and D. Accili. 2007. Analysis of compensatory beta cell response in mice with combined mutations of Insulin Receptor and Irs2. Am J Physiol Endocrinol Metab., 292(6):E1694-701
Fontana, L., Eagon, J.C., Trujillo, M.E., Scherer, P.E. and S. Klein. 2007. Visceral fat adipokine secretion is associated with systemic inflammation in obese humans. Diabetes, 56(4):1010-3
Ashton, A.W., Mukherjee, S., Nagajyothi, F., Huang, H., Braunstein, V.L., Desruisseaux, M.S., Factor S.M., Lopez, L., Berman, J.W., Wittner, M., Scherer, P.E., Capra, V., Coffman, T.M., Serhan, C.N., Gotlinger, K., Wu, K.K., Weiss, L.M. and H.B. Tanowitz. 2007. Thromboxane A2 is a key regulator of pathogenesis during Trypanosomacruzi infection. J Exp Med.,204(4):292-40